Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer Dollhouses stem cells (CSCs).To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in a panel of patient-derived cancer organoids.These studies demonstrated cancer organoid

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